optimizing treatment with pegylated interferon-ribavirin of genotype 3 chronic hepatitis c: more questions than answers
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Maintenance interferon for chronic hepatitis C: more issues than answers?
In this issue of HEPATOLOGY, Ikeda et al.1 describe use of long-term maintenance therapy with beta-interferon to prevent recurrent hepatocellular carcinoma (HCC) after surgical resection or alcohol ablation of primary HCC in patients with chronic hepatitis C virus (HCV). Twenty patients, 10 per group, were randomly assigned to either beta-interferon or no treatment after potentially curative su...
متن کاملconsensus interferon plus ribavirin for hepatitis c genotype 3 patients previously treated with pegylated interferon plus ribavirin
conclusions more than one-quarter of treatment-experienced patients with hcv genotype 3 achieved svr after re-treatment with consensus interferon plus ribavirin. objectives we aimed to assess the efficacy and safety of cifn and ribavirin in non-responders and relapsers to pegylated interferon with ribavirin therapy. patients and methods this open-label investigator-initiated study included 44 p...
متن کاملConsensus Interferon Plus Ribavirin for Hepatitis C Genotype 3 Patients Previously Treated With Pegylated Interferon Plus Ribavirin
BACKGROUND Not enough data are available about the effectiveness of consensus interferon (CIFN) among HCV genotype 3 patients who failed to respond to pegylated interferon and ribavirin. OBJECTIVES We aimed to assess the efficacy and safety of CIFN and ribavirin in non-responders and relapsers to pegylated interferon with ribavirin therapy. PATIENTS AND METHODS This open-label investigator-...
متن کاملEarly predictability of virological response in patients of chronic hepatitis-C with genotype-3, treated with pegylated interferon and ribavirin.
BACKGROUND This study was conducted to assess the early predictability of virological response in chronic hepatitis-C patients (Genotype-3), treated with pegylated interferon alpha-2a and ribavirin with an objective of determining predictive values of Rapid Virological Response (RVR) and Early Virological Response (ETR) on Sustained Virological Response (SVR). METHOD This cross sectional stud...
متن کاملAutoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C
Hepatitis flare is rarely observed during treatment with pegylated interferon alpha for hepatitis C virus (HCV) infection. A 49-year-old man receiving pegylated interferon α-2a for HCV infection had icterus and hyperbiliru-binemia in the 14th week of therapy, with HCV RNA undetectable after the 12th dose. Liver biopsy was suggestive of chronic hepatitis with cirrhosis without interface pattern....
متن کاملPegylated interferon-alfa plus ribavirin therapies for chronic hepatitis C.
Until HCV NS3/4A protease inhibitors become available at the end of 2011, the combination pegylated-interferon (PEG-IFN)-alfa and ribavirin (RBV) will remain the standard treatment for chronic hepatitis C patients. In some hepatitis C virus-infected patients, PEG-IFN plus RBV treatment against HCV should continue to be used because of side effects of new drugs such as anemia. Our Japanese exper...
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عنوان ژورنال:
hepatitis monthlyجلد ۸، شماره ۴، صفحات ۳۰۴-۳۰۹
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